Previously Funded Research

Lindsay LaFave, PhD

Albert Einstein College of Medicine

Research Project:

Investigating chromatin-mediated mechanisms of immune response in lung cancer

Summary:

This project was awarded the LCRF William C. Rippe Award for Distinguished Research in Lung Cancer, acknowledging the investigator whose proposal not only demonstrated exceptional scientific merit but also exemplified an enduring commitment to making an impact in the field of lung cancer research.

This research focuses on understanding how lung adenocarcinoma, particularly in smokers, develops and progresses. Using advanced organoid and mouse models, the study explores how alveolar type 2 (AT2) cells and immune cells interact under the influence of the key regulator CEBPA. By investigating how chronic inflammation and immune responses drive cancer development and affect treatment outcomes, the project aims to improve current therapies and develop new strategies, benefiting both smokers and non-smokers with lung cancer. This could lead to new therapeutic rationales for both smokers and non-smokers.