2011 Lung Cancer Research Foundation Annual Grant Program
Xianxin Hua, MD
University of Pennsylvania
Research Project:
Pharmacological suppression of oncogenic K-ras-induced lung cancer via activation of the menin pathway
Summary:
Lung cancer patients with a mutation called K- RAS have aggressive tumors that are resistant to commonly used treatments. The grant will study the effects of interfering with several preliminary mechanisms that lead to the K-RAS mutation as a means of blocking this mutation and causing more effective elimination of the lung cancer.