2011 Lung Cancer Research Foundation Annual Grant Program
Donald Kufe, MD
Dana-Farber Cancer Institute
Research Project:
Targeting the MUC1-C Oncoprotein in Drug Resistant NSCLC
Summary:
This grant extends previous LCRF support to study the MUC-1 oncoprotein, which is often found in high levels in lung cancer that are associated with shorter survival and resistance to common current treatments. Inhibitors to MUC-1 will be now evaluated in animal models and early human clinical trials to see if they are effective in decreasing the growth of these aggressive cancers.