2013 UALC
Subhajyoti De, PhD
University of Colorado Denver Anschutz Medical Campus
Research Project:
Identifying potential driver mutations in gene promoters in a cohort of completely sequenced NSCLC genomes
Summary:
Targeted therapies can be very effective in lung cancer patients whose tumors have specific driver mutations. However, 30% of lung tumors have no identifiable driver mutation within the classic cancer genes. Dr. De will perform a systematic survey to identify novel driver mutations that affect regulation of key cancer pathways in non-small cell lung cancer. This research aims to discover a new class of regulatory driver mutations in NSCLC, which contribute to tumor initiation and growth by changing expression of critical cancer genes.