2013 UALC
Ann Marie Pendergast, PhD
Duke University Medical Center
Research Project:
Novel druggable pathway required for lung cancer progression and metastasis
Summary:
Dr. Pendergast will investigate targeting the two Abl family kinases, Abl and Arg, in lung adenocarcinoma. Her team identified a role for Abl kinases in the progression and metastasis of some NSCLC tumors, characterized by poor prognosis and few therapeutic options. In addition, new data predicts Abl kinases to be involved in over 15% of lung tumors. Dr. Pendergast’s team will investigate the role of Abl kinases in lung adenocarcinoma tumor progression and metastasis, and test whether inhibiting Abl kinases can resensitize drug-resistance tumors to treatment.