2013 UALC
Alison Taylor, PhD
Dana-Farber Cancer Institute
Research Project:
Chromosomal Gains in Lung Squamous Carcinoma
Summary:
Chromosome numbers are altered in many tumors; instead of the normal two copies, the numbers vary. This is very common in lung squamous cell carcinomas (SCCs), where targeted treatments are currently not available. Over half of lung SCC patients have a particular chromosomal change — extra copies of one arm of chromosome 3, named chromosome 3q. Dr. Taylor will investigate the role of this chromosomal exchange in SCC through analyzing sequencing databases and utilizing various preclinical models. Validating this pathway in SCC will lay the groundwork for future development of new, targeted treatments.