2013 UALC
Sandra Hofmann, PhD
University of Texas Southwestern Medical Center
Research Project:
DHHC Protein Palmitoyltransferases in Small Cell Lung Cancer
Summary:
This project aims to identify a new class of targets for lung cancer therapy. Dr. Hofmann will be investigating a new family of enzymes (the DHHC family) that regulates protein function, focusing on DHHC5, an enzyme required for lung cancer growth. Her team will explore the role of DHHC5 in small cell lung cancer and understand the mechanism of DHHC5 protein overexpression in lung cancer. This work will help predict which patients would ultimately respond to drugs targeting this family of proteins.