2013 Lung Cancer Research Foundation Annual Grant Program
Katerina Politi, PhD
Yale University
Research Project:
The influence of tumor call-of-origin and heterogeneity on acquired resistance to targeted therapies in cancer
Summary:
Dr. Politi’s study will provide insight into the reprogramming of lung cancer cells; information on the cell of origin of different lung cancer subtypes; and clues to pharmacological and genetic approaches capable of altering the fate of lung adenocarcinomas and SCLC. More broadly, it will shed light on the evolution of cancers upon treatment with targeted therapies and mechanisms of resistance to these agents.