2013 Lung Cancer Research Foundation Annual Grant Program
Katja Lamia, PhD
The Scripps Research Institute
Research Project:
Determining the role of Cryptochromes during Lung Carcinogenesis
Summary:
Dr. Lamia’s study seeks to determine the role of circadian transcriptional repressors CRY1 and/or CRY2 in cellular proliferation and transformation in NSCLC models. The study also aims to establish the role of Cry1 and/or Cry2 in DNA damage response (DDR); identify target genes regulated by Cry1 and/or Cry2 that may explain the observed effects on proliferation, transformation, and DDR; and determine whether Cry2-dependent modulation of DNA-PKcs contributes to the observed effects on proliferation, transformation, and DNA damage response (DDR) in Cry2-/- cells.