2013 Lung Cancer Research Foundation Annual Grant Program
Thales Papagiannakopoulos, PhD
Massachusetts Institute of Technology
Research Project:
Elucidating the Role of Circadian Rhythm Disruption in Lung Tumorigenesis
Summary:
Dr. Papagiannakopoulos’s study will determine the effect of cell autonomous oncogenic events on circadian clock regulation to understand the relationship between transformation and circadian clock disruption. Furthermore, using a series of well-defined physiologic and genetic experimental approaches in vivo, his study will disrupt circadian rhythm homeostasis by systemic and conditional genetic loss-of-function of the core circadian clock components.