2013 Lung Cancer Research Foundation Annual Grant Program
Donald Kufe, MD
Dana-Farber Cancer Institute
Research Project:
Targeting the MUC1-C Oncoprotein with New Agents in Drug Resistant NSCLC
Summary:
Dr. Kufe’s research hopes to assess the effects of the MUC1-C/ED-Fc fusion protein in targeting the MUC1-C extracellular domain on the surface of EGFR mutant lung cancer cells. It also aims to investigate effective combinations of MUC1-C inhibitors with other targeted anti-cancer agents for lung cancer treatment.