2014 LCRF Scientific Grant Program
Don Nguyen, PhD
Yale University
Research Project:
Targeting Protein Metabolism to Treat Metastatic Lung Cancer
Summary:
Dr. Nguyen and his research team recently discovered a novel pathway that inhibits metastasis of lung adenocarcinoma (LuAd), the most frequent cancer sub-type. The aims of this project are to identify the molecular mechanism that links LASR and proteostasis to lineage de-differentiation in mestastatic LuAds, and to inhibit LuAd metastatic progression in vivo by perturbing the LASR.