2014 Lung Cancer Research Foundation Annual Grant Program
Xiaoyang Zhang, PhD
Dana-Farber Cancer Institute
Research Project:
MGA, a Novel Tumor Suppressor in Lung Cancer
Summary:
Dr. Zhang’s study will seek to characterize the role of MGA mutations in lung adenocarcinoma. It will assess the effects of MGA inactivation on diverse cellular phenotypes, identify the MGA target genes, and compare them to the MYC targets. Finally, Dr. Zhang seeks to determine the mechanism by which MGA regulate the expression of its target genes and characterize its role in modulating MYC activity.