2008 Lung Cancer Research Foundation Annual Grant Program
Marc Ladanyi, MD
Memorial Sloan Kettering Cancer Center
Research Project:
Harnessing New Genomic Technologies to Understand Lung Cancer
Summary:
The study of the impact of low expression of DUSP4 and EGFR mutations in lung cancer. Some lung cancers are now known to have EGFR mutations. A prior LCRF grant allowed identification of numerous other genes associated with various mutations in EGFR. This proposal will support a mouse model to identify the impact of what appears to be an important gMarene mutation combination in some lung cancers and how this effects the growth of such tumors in mice models. This understanding could lead to more effective treatments and new agents selective for these changes.