2009 UALC
Matthew Meyerson, MD, PhD
Dana-Farber Cancer Institute
Research Project:
Discovery of essential oncogenes in small cell lung cancer
Summary:
Dr. Meyerson’s project is focused on identifying new oncogenes in small cell lung cancer for future targeted therapies and improved understanding of the disease. He is using RNA interference and RNA sequencing technology to identify mutations and rearranged genes.
More Content:
Final Report
Dr. Meyerson has taken an integrated approach to analysis of small cell lung cancer genomes, comprising copy number analysis, transcriptome sequencing, and RNA interference analysis, revealing known and novel mutations and gene rearrangements. More recently, they have also looked at the intersection of RNA interference and gene expression data for SCLC. Using this analysis, they have found that knockdown of certain genes is selectively lethal for SCLC cells. Dr. Meyerson’s team is now in the process of validating these intriguing results.
Notable Accomplishments
Dr. Meyerson has received $150,000 from the American Lung Association to continue this project.