2012 UALC
Martin McMahon, PhD
University of California, San Francisco
Research Project:
The Role Of PI3'-Kinase Signaling In Lung Cancer Initiation & Maintenance
Summary:
The PI3’-Kinase (PI3K) pathway is major growth-promoting pathway activated by multiple drivers of lung cancer, including Kras and EGFR. There are many PI3K inhibitors currently in clinical development, yet it remains unclear how best to deploy these drugs to treat lung cancer patients. Dr. McMahon will be investigating a number of inhibitors against this pathway using cell lines and pre-clinical models to better understand how this pathway contributes to lung cancer growth. This work will ultimately inform development of novel single-agent and combination therapies targeting the PI3K pathway to improve treatment strategies for lung cancer patients.