2014 Lung Cancer Research Foundation Annual Grant Program
Faye Johnson, MD, PhD
MD Anderson Cancer Center
Research Project:
Mechanisms that Regulate Response to Targeted Agents in Lung Cancer
Summary:
Dr. Johnson’s study seeks to define the mechanisms of susceptibility and resistance to PLKI inhibitors to lay the foundation for a clinical trial and advances in our understanding of PLKI. The future plans include validating these biomarkers prospectively in vivo in a co-clinical trial with diverse patient-derived xenograft (PDX) models and a biomarker-selected clinical trial.
This project has received multiple year funding.