2014 Lung Cancer Research Foundation Annual Grant Program
Victoria Wang, MD, PhD
The Regents of the University of California
Research Project:
Understanding How Changes in the Cytoskeleton of Lung Cancer Cells Make Them Survive Better and More Resistant to Drugs
Summary:
Preliminary data for this study implicates regulation of the cytoskeleton via the Rho-A-ROCK-myosin pathway as an important factor in this process. This study investigates the mechanism by which inhibition of this pathway promotes cellular survival to explore the use of myosin as a biomarker in predicting response to therapy and to identify pharmacological agents that may selectively target this cell population.