2014 Lung Cancer Research Foundation Annual Grant Program
Bruce Zetter, PhD
Boston Children’s Hospital
Research Project:
Targeting Lung Cancer Resistance Through Prohibition I
Summary:
Dr. Zetter and his team will compare these verified interactions between chemo-sensitive and resistant cells and will examine whether such interactions are crucial for conferring chemoresistance. The hypothesis is that PHBI mediates chemoresistance through scientific interactions with apoptosis-modulating proteins, leading to a state of reduced apoptosis and reduced drug sensitivity. The project will consequently focus on PHBI-interacting proteins that have known roles in apoptosis pathways.