2014 Lung Cancer Research Foundation Annual Grant Program
Linda Malkas, PhD
City of Hope Medical Center
Research Project:
A Potential New Pathway for Treating Small Cell Lung Cancer (SCLC)
Summary:
Dr. Malkas’ research proposes three aims: 1) to establish a role for RS in SCLC, 2) to evaluate caPep’s capacity to obstruct caPCNA interactions/functions and promote higher levels of SCLC RS and DNA damage repair responses and 3) to determine caPep’s ability to promote enhanced SCLC sensitivity, especially in SCLC with MYC-amplification, in combination with targeted therapies.