2014 Lung Cancer Research Foundation Annual Grant Program
Yanis Boumber, MD, PhD
The Research Institute of Fox Chase Cancer Center
Research Project:
Evaluation of a New Class of Highly Tumor-Specific Drugs in Both Small and Non-Small Cell Lung Cancer
Summary:
This study proposes mechanistic and preclinical studies of STA-12-8666, the lead member of a new compound class with significant promise for difficult-to-treat cancers. STA-12-8666 exploits the fact that stresses existing within tumors highly induce and activate heat shock protein 90 (Hsp90), as tumors become dependent on Hsp90 function.