2015 Lung Cancer Research Foundation Annual Grant Program
Vaishali Kapoor, PhD
Washington University in St. Louis
Research Project:
Activation of the immune system by antibodies binding to radiotherapy-induced antigens improves lung cancer control
Summary:
Lung cancer is the number one cause of cancer death worldwide. Treatment options vary depending on the type and stage of lung cancer, but include surgery, radiation, chemotherapy and/or targeted therapy. Despite advances in current treatment, there is a need to develop novel strategies to control lung cancer. In her project, Dr. Kapoor will use X-rays to guide antibodies specifically to lung cancer cells while sparing normal tissue. These antibodies will then activate the patient’s immune system to kill lung cancer cells. Previously, Dr. Kapoor and her team have discovered several radiation-inducible antigens. TIP1 is one such surface antigen expressed on lung cancer cell surface after irradiation. Targeting this antigen with monoclonal antibodies activates antibody-dependent immune cell activation and in turn a systemic immune response to control lung cancer. Specific targeting of cancer cells only, will minimize non-specific side-effects. The outcomes of this proposal will the team to further develop antibodies to lung cancer specific radiation-induced TIP1 antigen for conducting preclinical efficacy studies.