Previously Funded Research

Tikvah Hayes, PhD

David Geffen School of Medicine at UCLA

Research Project:

Advancing preclinical cell line diversity and decoding TKI-resistance landscapes in EGFR-mutant lung cancer

Summary:

This project was awarded the Cynthia M. Page Merit Award for Innovation in Lung Cancer, which is awarded to the investigator whose proposal demonstrates exceptional scientific merit and groundbreaking innovation, pushing the boundaries of lung cancer research with creative, forward-thinking approaches.

Treatment resistance remains a major challenge for patients with EGFR-mutant lung cancer. This project aims to shed light on how different mutations in EGFR affect cellular biology and response to treatment. The team will develop new models to study understudied mutations and use advanced genetic techniques to identify mutations that cause resistance to current therapies. By uncovering these mechanisms, the study could lead to better treatments and improved outcomes for patients with EGFR-mutant lung cancer, advancing the field of lung cancer research.