2024 LCRF Research Grant on Early Detection and Pre-Neoplasia in Lung Cancer
Peggy Hsu, MD, PhD
University of Michigan
Research Project:
Understanding the origin of ALK-driven lung cancer
Summary:
ALK-positive lung cancer, often affecting non-smokers and diagnosed at advanced stages, has unclear origins. This research aims to uncover the earliest events driving ALK-driven lung cancer using advanced single-cell technologies. By studying patient samples, lung organoids, and mouse models, the team will map how ALK activation leads to tumor initiation. The findings could reveal novel molecular features, enhance our understanding of cancer cell plasticity, and pave the way for earlier detection and prevention strategies, improving survival rates for ALK+ lung cancer patients.