2024 LCRF Research Grant on Understanding Resistance in Lung Cancer
Megan Burger, PhD
Oregon Health & Science University
Research Project:
Optimizing immunotherapy sequencing to overcome resistance
Summary:
This project aims to enhance cancer immunotherapy by combining immune checkpoint blockade (ICB) therapy with cancer vaccines to overcome resistance and extend the benefits of treatment to more patients. Using a mouse model of lung adenocarcinoma, the study will explore how these therapies work together, optimizing vaccine dosing and timing relative to ICB treatment for maximum effectiveness. The findings could inform clinical trials, improve response rates, prevent disease recurrence, and ultimately lead to better outcomes for lung cancer patients.